找出一段DNA的最长回文子串。

问题描述 投票:2回答:1

我要做一个函数,打印一段DNA中最长的回文子串。我已经写了一个函数来检查一段DNA本身是否是一个词缀。请看下面的函数。

def make_complement_strand(DNA):
    complement=[]
    rules_for_complement={"A":"T","T":"A","C":"G","G":"C"}
    for letter in DNA:
        complement.append(rules_for_complement[letter])
    return(complement)

def is_this_a_palindrome(DNA): 
        DNA=list(DNA)
        if DNA!=(make_complement_strand(DNA)[::-1]):     
            print("false")                  
            return False
        else:                             
            print("true")
            return True

is_this_a_palindrome("GGGCCC") 

但是现在:如何制作一个打印DNA字符串最长的palindrome子串的函数?

在遗传学的背景下,palindrome的含义与用于单词和句子的定义略有不同。由于双螺旋是由两条成对的核苷酸链形成的,这两条核苷酸链在5'-到3'的意义上运行方向相反,而且核苷酸总是以相同的方式配对(DNA的腺嘌呤(A)与胸腺嘧啶(T),RNA的乌拉基尔(U);胞嘧啶(C)与鸟嘌呤(G)),因此,如果一个(单链)核苷酸序列与它的反向补码相等,就说它是一个顺位。例如,DNA序列ACCTAGGT是palindromic,因为它的核苷酸比补码是TGGATCCA,把补码中的核苷酸顺序颠倒过来,就会得到原始序列。

python python-3.7 palindrome dna-sequence
1个回答
1
投票

在这里,这应该是获取最长手印子串的一个不错的起点。

def make_complement_strand(DNA):
    complement=[]
    rules_for_complement={"A":"T","T":"A","C":"G","G":"C"}
    for letter in DNA:
        complement.append(rules_for_complement[letter])
    return(complement)

def is_this_a_palindrome(DNA): 
        DNA=list(DNA)
        if DNA!=(make_complement_strand(DNA)[::-1]):     
            #print("false")                  
            return False
        else:                             
            #print("true")
            return True


def longest_palindrome_ss(org_dna, palindrone_func):
    '''
    Naive implementation-

    We start with 2 pointers.
    i starts at start of current subsqeunce and j starts from i+1 to end
    increment i with every loop

    Uses palindrome function provided by user

    Further improvements- 
    1. Start with longest sequence instead of starting with smallest. i.e. start with i=0 and j=final_i and decrement.
    '''
    longest_palin=""
    i=j=0
    last_i=len(org_dna)
    while i < last_i:
        j=i+1
        while j < last_i:
            current_subsequence = org_dna[i:j+1]
            if palindrone_func(current_subsequence):
                if len(current_subsequence)>len(longest_palin):
                    longest_palin=current_subsequence
            j+=1
        i+=1
    print(org_dna, longest_palin)
    return longest_palin


longest_palindrome_ss("GGGCCC", is_this_a_palindrome)
longest_palindrome_ss("GAGCTT", is_this_a_palindrome)
longest_palindrome_ss("GGAATTCGA", is_this_a_palindrome)

下面是一些执行结果 -

mahorir@mahorir-Vostro-3446:~/Desktop$ python3 dna_paln.py 
GGGCCC GGGCCC
GAGCTT AGCT
GGAATTCGA GAATTC
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